Антипенко Олексій Миколайович


старший викладач

кандидат фармацевтичних наук

Дата народження: 24-05-1990

Тема дисертаційної роботи:

Тетразоло[1,5]хіназолін-(6Н)-5-они(тіони): синтез, функціоналізація, фізико-хімічні та біологічні властивості, виконується.

Наукові інтереси:

The main areas of research are: Synthesis of the novel biologically active compounds among condensed heterocycles, namely derivatives of tetrazolo- and triazolo[1,5-c]quinazolines, evaluation of their structure by physico-chemical data (IR, UV, 1H and 13C NMR, LC-MS, EI-MS spectra) and biological activity: antibacterial, antifungal, bioluminescence inhibitive, retardant and antitumor. SAR and QSAR analysis, docking. Number of articles13, abstracts24, patent1, etc.

Біографія:

September 2007 – June 2012. Bachelor of Science, Pharmacy, Zaporizhzhya State Medical University, Pharmacy Faculty, Ukraine. December 2012 – June 2013. Master of Science, Pharmacy, Zaporizhzhya State Medical University, Organic and Bioorganic Chemistry Department, Pharmacy Faculty, Ukraine. December 2013 till December 2016 PhD Student, Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University, Ukraine. December 2016 till Jenuary 2018 Scientific Assistant, Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University, Ukraine. Jenuary 2018 till now Assistant professor (Senior Lecturer), Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University, Ukraine.

Основні публікації:

  1. Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides / G.G. Berest, A.Yu. Voskoboynik, S.I. Kovalenko, A.M. Antypenko, I.S. Nosulenko, A. M. Katsev, A.S. Shandrovskaya // European Journal of Medicinal Chemistry. – 2011. – Vol. 46, Issue 12. – P. 6066-6074.
  2. Synthesis of new 6-{[ω-(dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]-triazino[2,3-c]quinazoline-2-ones and evaluation of their anticancer and antimicrobial activities / G.G. Berest, O.Yu. Voskoboynik, S.I. Kovalenko, I.S. Nosulenko, L.M. Antypenko, O.M. Antypenko, V.M. Shvets, A.M. Katsev // Scientia Pharmaceutica. – 2012. – Vol. 80, Issue 1. – Р. 37-65.
  3. N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecules. Synthesis, physico-chemical properties, cytotoxicity research by bioluminescence inhibition, anticancer activity / Sergey I. Kovalenko*, Inna S. Nosulenko, Alexey Yu. Voskoboynik, Galina G. Berest, Lyudmyla M. Antypenko, Alexey N. Antypenko, Andrey M. Katsev // Sci. Pharm. – 2012. – Vol. 80. – P. 837–865.
  4. Design and Evaluation of Novel Antimicrobial And Anticancer Agents Among Tetrazolo[1,5-c]Quinazolin-5-Thion S-Derivatives / L. M. Antypenko, O. M. Antypenko, S. I. Kovalenko, O. M. Achkasova // Scientia Pharmaceutica. – 2013. – Volume 81, Issue 1. – P. 15–42.
  5. Novel N-aryl(alkaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]-acetamides: synthesis, cytotoxicity, anticancer activity, compare analysis and docking. / S. I. Kovalenko, I. S. Nosulenko, A. Yu. Voskoboynik, G. G. Berest, L. M. Antypenko, A. N. Antypenko, A. M. Katsev// Medicinal Chemistry Research. – 2013, V. 22, Issue 6. – P. 2610-2632
  6. Synthesis and anticancer activity of 2-аlkyl(alkaryl-, aryl-, heteryl-)-[1,2,4]triazolo[1,5-c]quinazolines / S. I. Kovalenko, L. M. Antypenko, A. K. Bilyi, S. V. Kholodnyak, O. V. Karpenko, O. M. Antypenko, N. S. Mykhaylova, T. I. Los’, O. S. Kоlоmоеts’ // Scientia Pharmaceutica. – 2013. – V.81, Issue 2. – P. 359–391.
  7. 2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6Н)-thiones and their S-substituted derivatives: synthesis, spectral data and biological activity /A. K. Bilyi, L. M. Antypenko, V. V. Ivchuk, O. M. Kamyshnyi, N.M. Polishchuk, S. I. Kovalenko // ChemPlusChem. – 2015. – Vol. 80. – P. 980-989.
  8. O. M. Antypenko, S. I. Kovalenko, S. D. Trzhetsinsky Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones // Запорізький медичний журнал. – 2016. – №1(94). – С. 81-84.
  9. Synthesis and hydrolytic cleavage of tetrazolo[1,5-c]quinazolines / O. M. Antypenko, S. I. Kovalenko, O. V. Karpenko // Synthetic Communications – 2016. – Vol. 46(6). – P. 551-555
  10. Antypenko O., Kovalenko S., Shernova G. Search compounds with hypoglycemic activity in the series of 1-(2-1H-tetrazol-5-yl)-R-phenyl-)3-R-phenyl(ethyl)ureas and R-tetrazolo[1,5-c]quinazolin-5(6H)-ones // Sci Pharm. – 2016. – Vol. 84. – P. 233–254.
  11. Synthesis, anticancer and QSAR studies of 2-alkyl(aryl,hetaryl)-quinazolin-4(3H)-thione’s and [1,2,4]triazolo[1,5-c]quinazoline-2-thione’s thioderivatives. / L.М. Antypenko, O.M. Antypenko, S.I Kovalenko, O.V. Karpenko, V.O. Nikitin .// Helvetica Chimica Acta. – 2016. – Vol.99. – P.1-11.
  12. Synthesis of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, anticancer activity and QSAR modeling / Oleksii M. Antypenko, Sergiy I. Kovalenko, Bakhtiyor F. Rasulev, Jerzy Leszczynsk // ACTA CHIMICA SLOVENICA. – 2016. – Vol.63. – 638-645.
  13. 5,6-Dihydro-[1,2,4]triazolo[1,5-с]quinazolines. Message 4. Spirocompounds with [1,2,4]triazolo[1,5-c]quinazolines moieties. Synthesis and spectral characteristics / Kholodnyak S.V, Schabelnyk K.P., Аntypenko O.M., Кovalenko S.I., Palchykov V.A., Okovyty S.I., Shishkina S.V // Journal of Organic and Pharmaceutical Chemistry. – 2016. Vol. 14. – №3(55). – Р. 24-31.
  14. Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents /Olexii M. Antypenko, Lyudmyla M. Antypenko, Sergiy I. Kovalenko, Andrey M. Katsev, Olena M. Achkasova // Arabian Journal of Chemistry. Volume 9, Issue 6, November 2016, P.  792–805
  15. Antypenko, O. M., Kovalenko, S. I., Karpenko, O. V., Nikitin, V. O. and Antypenko, L. M. (2016), Synthesis, Anticancer, and QSAR Studies of 2-Alkyl(aryl,hetaryl)quinazolin-4(3H)-thione’s and [1,2,4]Triazolo[1,5-c]quinazoline-2-thione’s Thioderivatives. Helv. Chim. Acta, 99: 621–631.