Воскобойнік Олексій Юрійович


доцент

кандидат фармацевтичних наук

Дата народження: 13-05-1981

Основні публікації:

  1. An Efficient Synthesis of 3-R-6-thio-6,7-dihydro-2Н-[1,2,4]triazino[2,3-c]-quinazoline-2-ones and its Derivatives, Antimicrobial and Antifungal Activity/ G. G. Berest, A.Yu. Voskoboynic, S. I. Kovalenko, R. S. Sinyak, I.V. Omelchenko, O. V. Shishkin, E. Komarovska-Porokhnyavets, V.P. Novikov // Журнал органічної та фармацевтичної хімії. – 2010. – Т. 8, Випуск 3(31). – С. 42-52.
  2. Voskoboynik A.Yu., Berest G.G., Skorina D. Yu., Karpenko A.V., Kovalenko S.I. Synthesis of 6-R-3-(2-aminophenyl)-4Н-[1,2,4]thriazin-5-ones: resources and limitations // Chemistry & Chemical Technology. – Lviv Polytechnic National University. – 2011. – Vol.5, № 2. – Р.129-132.
  3. Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides / G.G. Berest, A.Yu. Voskoboynik, S.I. Kovalenko, A.M. Antypenko, I.S. Nosulenko, A. M. Katsev, A.S. Shandrovskaya // European Journal of Medicinal Chemistry. – 2011. – Vol. 46, Issue 12. – P. 6066-6074.
  4. Synthesis of new 6-{[ω-(dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]-triazino[2,3-c]quinazoline-2-ones and evaluation of their anticancer and antimicrobial activities / G.G. Berest, O.Yu. Voskoboynik, S.I. Kovalenko, I.S. Nosulenko, L.M. Antypenko, O.M. Antypenko, V.M. Shvets, A.M. Katsev // Scientia Pharmaceutica. – 2012. – Vol. 80, Issue 1. – Р. 37-65.
  5. N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecules. Synthesis, physico-chemical properties, cytotoxicity research by bioluminescence inhibition, anticancer activity / Sergey I. Kovalenko*, Inna S. Nosulenko, Alexey Yu. Voskoboynik, Galina G. Berest, Lyudmyla M. Antypenko, Alexey N. Antypenko, Andrey M. Katsev // Sci. Pharm. – 2012. – Vol. 80. – P. 837–865.
  6. [5+1]-Heterocyclisation in synthesis of as-triazino[2,3-c]quinazoline systems / O. Yu. Voskoboynik, O. V. Karpenko, T.Yu. Sergeieva, S. I. Kovalenko, S. I. Okovytyy // Журнал органічної та фармацевтичної хімії. – 2013. – T.11, Вип. 1(41). – С.37-44.
  7. Novel N-aryl(alkaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]-acetamides: synthesis, cytotoxicity, anticancer activity, compare analysis and docking. / S. I. Kovalenko, I. S. Nosulenko, A. Yu. Voskoboynik, G. G. Berest, L. M. Antypenko, A. N. Antypenko, A. M. Katsev// Medicinal Chemistry Research. – 2013, V. 22, Issue 6. – P. 2610-2632
  8. Synthesis and anticancer activity of 2-аlkyl(alkaryl-, aryl-, heteryl-)-[1,2,4]triazolo[1,5-c]quinazolines / S. I. Kovalenko, L. M. Antypenko, A. K. Bilyi, S. V. Kholodnyak, O. V. Karpenko, O. M. Antypenko, N. S. Mykhaylova, T. I. Los’, O. S. Kоlоmоеts’ // Scientia Pharmaceutica. – 2013. – V.81, Issue 2. – P. 359–391.
  9. Tautomerism of the 4-hydrazinoquinazolines: vibrational spectra and computational study / T. Yu. Sergeieva, O. Yu. Voskoboynik, S. I. Okovytyy, S. I. Kovalenko, Jerzy Leszczynski // Вісник Дніпропетровського університету. Серія «Хімія», 2013. Вип. № 19. – Р. 35-43.
  10. Hydrazinolysis of 3‑R‑[1,2,4]Triazino[2,3-c]quinazolin-2-ones. Synthetic and Theoretical Aspects / T. Yu. Sergeieva, O. Yu. Voskoboynik, S. I. Okovytyy, S. I. Kovalenko, Sv. V. Shishkina, O. V. Shishkin, J. Leszczynski // J. Phys. Chem. A. – 2014. – 118. – P. 1895−1905.
  11. Synthesis аnd аntiviral activity [9-R1-10-R2-3-R-2-оxo-2H-[1,2,4]-triazino[2,3-с]quinazolin-6-yl)thio]acetamides derivatives with the fragments of carcase аmines / I. S. Nosulenko, O. Yu. Voskoboynik, G. G. Berest, S..L. Safronyuk, S. I. Kovalenko, An. V.Katsev, R. S. Sinyak // Journal of Organic and Pharmaceutical Chemistry. – 2014. – Vol. 12, Iss. 1 (45). – Р. 17-27.
  12. Synthesis 3-R-8-R1-9-R2-10-R3-R-6-thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones, its antibacterial and antifungal activity / I. S. Nosulenko, O. Yu. Voskoboynik, G. G. Berest, S. L. Safronyuk, S. I. Kovalenko, O. M. Kamyshnyi, N. M. Polishchuk, R. S. Sinyak, A. V.Katsev // Sci Pharm. – 2014. – Vol.82: – P. 483–500.
  13. The structure optimization of [(2-R-quinazolin-4-ylidene)hydrazono]carboxylic acids and esters – intention of search a new class of substances with anticancer activity / O.Yu.Voskoboynik , O.V.Karpenko , S.I.Kovalenko , G.G.Berest , V.V.Ivchuk , V.M.Shvets // Journal of Organic and Pharmaceutical Chemistry. – 2014. – Vol. 12, Iss. 4 (48). – P. 3-20.
  14. Synthesis and modification of 2-[8-R1-9-R2-10-R3-3-R-2-оxo-2Н-[1,2,4]triazino[2,3-с]quinazoline-6-yl)thio]acetic acids aimed to the search of effective substances with antibacterial and antifungal activity / I. S. Nosulenko, O. Yu. Voskoboynik, G. G. Berest2, S. I. Kovalenko, O. M. Kamyshnyi, N. M. Polishchuk // Вісник фармації. – 2015. – №1. – С. 11-20.
  15. Features of interaction between 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones and cyclic anhydrides of non-symmetric dicarboxylic / Voskoboynik O.Yu., Skorina D.Yu., Shishkina S.V., Shishkin O.V., Kovalenko S.I., V.V. Ivchuk // Journal of Organic and Pharmaceutical Chemistry. – 2015. – Т. 13, вип. 1 (49). – Р. 25-31.
  16. Voskoboynik O.Yu. Synthesis, physicochemical properties and anticancer activity of 6-(heterocyclyl-N-ylmethyl)-3-R1-9-R2-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones // Вопросы химии и химической технологии. – 2015. – Т. 1 (99). – С. 9-12.
  17. Скорина Д,Ю., Воскобойник А.Ю., Коваленко С.И. Синтез и противораковая активность N-замещенных фталиламидов с триазиновым фрагментом // Фармация Казахстана. – 2015. – №6(169). – C. 36-41.
  18. Hydrolytic cleavage of pyrimidine ring in 2-aryl-[1,2,4]triazolo[1,5-c]-quinazolines: physicо-chemical properties and hypoglycemia activity of the synthesized compounds / S.V.Kholodnyak, K.P.Schabelnyk, G.О.Zhernova, T.Yu.Sergeieva, V.V.Ivchuk, O.Yu.Voskoboynik, S.І.Kоvalenko, S.D.Trzhetsinskii, S.I.Okovytyy, S.V.Shishkina // NEWS OF PHARMACY. – 2015, №3(83). – Р. 9-17.
  19. Voskoboynik O.Yu. Synthesis, physicochemical and biological properties of 6-S- and 6-N-substituted 3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones / Вопросы химии и химической технологии. – 2015. – №4(102). – C. 9 – 16  
  20. 5,6-Dihydro-[1,2,4]triazolo[1,5-с]quinazolines. Message 1. Features of interactions between [2-(3-aryl-1H-1,2,4-triazole-5-yl)phenyl]amines, aliphatic and aromatic aldehydes. / S.V. Kholodnyak, K.P. Schabelnyk,, O.Yu. Voskoboynik, G.G. Berest, S.I. Kovalenko // Journal of Organic and Pharmaceutical Chemistry. – 2015. – Vol.13, Iss. 4(52). – P. 50-56.
  21. 5,6-Dihydro-[1,2,4]triazolo[1,5-с]quinazolines. Message 2. [5+1]-cyclocondensation of [2-(3-aryl-1H-1,2,4-triazol-5-yl)phenyl]amines with aliphatic and aromatic ketones // S.V. Kholodnyak, K.P. Schabelnyk, O.Yu. Voskoboynik, L.M. Antypenko, G.G. Berest, S.I. Kovalenko // // Journal of Organic and Pharmaceutical Chemistry. – 2016. – Vol.14, Iss. 1(53). – P. 24-29.
  22. Interaction of 3-(2-Aminophenyl)-6-R1-1,2,4-triazin-5-ones with Acylating Reagents: An Efficient Method for Preparation of 6-Substituted 3-R1-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones / Alexey Yu. Voskoboynik, Dmitriy Yu. Scorina, Tetiana Yu. Sergeieva, Sergiy I. Kovalenko, Sergiy I. Okovytyy, Irina V. Omelchenko, Oleg V.Shishkin // J. Het. Chem. – 2016. – Vol. 53, Issue 3. – P. 776-783.
  23. Synthesis, anticancer and FGFR1 inhibitory activity of isoindolo[2,1-a][1,2,4]triazino[2,3-c]quinazoline derivatives / O. Yu. Voskoboynik , S. A. Starosyla , M. V. Protopopov , H. P. Volynets, S. V. Shyshkina , S. M. Yarmoliuk, S. I. Kovalenko // Медична та клінічна хімія. – 2016. – Т. 18,  № 1(66). – P. 5-18.
  24. 6-Mono- and 6,6-disubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones – promising class of аnticancer agents / О.Yu.Voskoboynik, I.S.Nosulenko, G.G. Berest, S.I. Kovalenko // Український біофармацевтичний журнал. – 2016– № 2 (43). – С.71-78.
  25. 3-R1-8-R2-10-R3-2H-benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones – novel high electro-deficient heterocyclic compounds with promising anticancer activity / Voskoboynik O.Yu., Кovalenko S.I., Shishkina Sv. V. // Heterocyclic Communications. –  2016. – Vol. 22(3).  – P. 137–141
  26. 5,6-Dihydro-[1,2,4]triazolo[1,5-с]quinazolines. Message 3. Synthesis of 5-trichloromethyl-2-Aryl-5,6-dihydro-[1,2,4]-triazolo[1,5-с]quinazolines and features of their reactivity towards N-nucleophiles. / Sergiy V. Kholodnyak, Olexii Yu. Voskoboynik, Sergiy I. Kovalenko, Tatiana Yu. Sergeieva, Sergiy I. Okovytyy, Svitlana V. Shishkina // Journal of Organic and Pharmaceutical Chemistry. – 2016. – Vol.14. –Is.2(54). – P.47-52.
  27. 6-Thio-Subsrituted-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones with dialkylamino¬ethyl moiety – a new class of antivirial agents / O.Yu. Voskoboynik, G.G.Berest, I.S. Nosulenko, L.N. Antypenko, O.V. Krivoschey, V.N. Shvets, S.I. Kovalenko / Вісник фармації. – 2016. – №2(86). – С. 54-58.
  28. Voskoboynik, O. Y., Кovalenko, S. I., Okovytyy, S. I., and Shishkina, S. V. (2017) Dimethyl Acetylenedicarboxylate in Reactions with Substituted 3-(2-aminophenyl)-6-R1-1,2,4-triazin-5-(2H)-ones: Structure and Properties of the Products. J. Heterocyclic Chem., doi: 10.1002/jhet.2801.