Коваленко Сергій Іванович


сurriculum vitae

Name, surname                         Serhii Ivanovich Kovalenko (в украинской транскрипции)
 
Date of birth:                            01.10.1962
 
Address: Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy, 


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Name, surname                         Serhii Ivanovich Kovalenko (в украинской транскрипции)
 
Date of birth:                            01.10.1962
 
Address: Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy, Zaporizhzhia State Medical University
Mayakovsky Av. 26, 69035, Zaporizhzhia, Ukraine
Phone: +38(061)2246469; +38(061)2398586 (Department); +38(097)6876889
Fax: +38(061)2336007
 
E-mail: kovalenkosergiy@gmail.com
 
Scientific and educational degree      Dr. Prof.
 
Habilitation, DSc   2000, Zaporizhzhia State Medical University, Ukraine, Department of Pharmaceutical Chemistry. Thesis title: «Synthesis, transformation, physicochemical and biological properties of quinazolone-4 and 4-aminoquinazolines». Supervisor: prof. Ivan Mazur.
PhD                      1991, Zaporizhzhia State Medical University, Ukraine, Department of Pharmaceutical Chemistry. Thesis title: «Synthesis, physicochemical and biological properties 1,4-derivative quinazolines». Supervisor: prof. Ivan Mazur.
MSc                     1985, Zaporizhzhia State Medical University, Ukraine, Department of Pharmaceutical Chemistry. Thesis title: Synthesis and biological properties new 4-arylaminoquinazolines». Supervisor: prof. Ivan Mazur, assoc. prof. Raisa Sunyak.
 
Sciences field and Area of Science
Medical and Health Sciences, Pharmacy – M 003
 
Professional career
 
Since 2012      Head Department of the Organic and Bioorganic Chemistry at Zaporizhzhia State Medical University
2004-2012      Professor of the Department of Pharmaceutical Chemistry at Zaporizhzhia State Medical University
2000-2004          Assoc. prof (docent) of the Department of Pharmaceutical Chemistry at Zaporizhzhia State Medical University
1998-2000      Senior Lecturer of the Department of Pharmaceutical Chemistry at Zaporizhia State Medical University.
1989-1998      Research assistant of the Department of Pharmaceutical Chemistry at Zaporizhia State Medical University.
1988-1989      Senior laboratory assistant of the Department of Pharmaceutical Chemistry at Zaporizhia State Medical University.
185-1988        Head of pharmacy-shop Novoukrainka town, Kirovohrad region, Ukraine
 
Professional memberships
Ø  Member of the Exert Council of the Ministry of Education of Ukraine on Theoretical and Preventive Medicine and Pharmacy
Ø  Member of the Academic Council at Zaporizhia State Medical University
Ø  Deputy Chairman of the Specialized Academic Council for the Defense of Dissertations D.17.600.03 at Zaporizhia State Medical University.
Ø  Member of the commission for attestation of pharmaceutical personnel of Zaporizhia region
 
International Activity
Ø  Collaboration with National Cancer Institute, NIAID, Southern Research Institute, NINDS (NIH, Bethesda, Maryland, USA)
Ø  Visiting Professor of on Technical University of Liberec (Institute for Nanomaterials, Advanced Technologies and Innovation – 2012
Ø  Visiting Professor of on Neubrandenburg University of Applied Sciences – 2019
 
Editorial & Advisory Boards
«Zaporozhye medical journal» (Ukraine), «Journal of Organic and Pharmaceutical Chemistry» (Ukraine), «Pharmacon» (Ukraine), «Clinical Pharmacy, Pharmacotherapy and Medical Standardization» (Ukraine), «Current issues in pharmacy and medicine: science and practice» (Ukraine),
 
Supervisions of dissertations
Krasovska N.I. PhD (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Carboxyl-containing [1,2,4]triazolo[1,5-c]quinazolines and their functional derivatives: synthesis, physicochemical properties and anti-inflammatory activity»
Kholodniak O.V. PhD (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «N-(R-Carbamothioyl)cycloalkylcarboxamides: synthesis, modification, physicochemical and biological properties»
Stavytskyi V.V. (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Pyrrolo(pyrido)[1,2-a]triazolo(triazino)[c]quinazolines: synthesis, modification, physicochemical and biological properties»
Shabelnyk K.Р. Dsc (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 5-substituted 2-R-[1,2,4] triazolo[c] - and 2-R-5,6-dihydro- [1,2,4] triazolo[c]quinazolines»;
Voskoboynik O. Yu. Dsc (2019), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «[1,2,4]Triazino[c]quinazolines: synthesis, transformations, physicochemical and biological properties»
Logoida L.S. Dsc (2019),Ternopil National Medical University, Ternopil, Ukraine. Thesis title: «Scientific and theoretical substantiation of bioanalytical research and standardization of antihypertensive drugs using chromatographic methods»;
Martynenko Yu.V. PhD (2019), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «{([1,2,4]Triazolo[1,5-c]quinazolin-2-yl)alkyl-(alkaryl-, alkhetaryl-, aryl-)}amines and their imides: synthesis, chemical modification, physico-chemical and biological properties of the synthesized compounds»;
Kolomoets O.S. PhD (2018), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 6-mono- and 6,6-disubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-оnes»;
Antypenko O.M. PhD (2016), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Tetrazolо[1,5-c]quinazoline(6H)-5-ones(thiones): synthesis, functionalization, physico-chemical and biological properties»;
Kholodnyak S.V. PhD (2016), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «[(3-Аryl-1H-1,2,4-triazol)phenyl]amines: synthesis, chemical modification, physicochemical and biological properties of the synthesized compounds»;
Nosulenko I. S. PhD (2015), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physico-chemical and biological properties of 2-[(3-R-2-оxo-2Н-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetic acids and then substituted»;
Skorina D.Yu. PhD (2015), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties  (3-R-2-oxo-2H-[1,2,4]­triazino[2,3-c]quinazolin-6-yl)carbonic acids and their derivatives»
Biliy A. K. PhD (2014), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, transformation, physico-chemical and biological properties of 5-substituted 2-heteryl[1,2,4]triazolo[с]quinazolines»;
Voloschina V.A. PhD (2011), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physico-chemical and biological properties of substituted for 1,2,4-triazoles and its condensed derivates»;
Аvramenko А.І. PhD (2011), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Directed search for hepatoprotectors with antioxidant mechanism of action among 4-thioquinazoline derivatives based on the laws of the relationship "structure-action»
Аntypenko L.M. PhD (2010), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties S-derivatives of 2-thio[1,2,4]triazolo[1,5-c]quinazolines»;
Krivoshey O.V. PhD (2009), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of derivatives (6-R-3-oxo-2,3-dihydro-4H-[1,2,4]triazino[4,3-c]quinazoline-4-yl)acetic acid»
Voskoboynik O. Yu. PhD (2008), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, transformation, physicochemical and biological properties of [{2-R- (3H-quinazolin-4-ylidene}hydrazone]carboxylic acids»;
Karpenko O.V.  PhD (2007), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis of annulus heterocyclic compounds of 4-hydrazinoquinazoline derivatives and their biological activity»;
Nikitin V.A. PhD (2007), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 2-R-quinazolin-4-one (thione) derivatives»;
Shabelnyk K.P. PhD (2007), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of amides (6-R-4-oxo-4H-quinazolin-3-yl)alkyl(aryl-)carboxylic acids»;
Nesterova N.O. PhD (2005), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 4-hydrazinoquinazoline derivatives».
 
publucations
Authors of 318 scientific papers (68 Scopus), 61 patents, 423 conference and workshops communications, co-autors of the book «Antimalarial drugs. Quinine and its analogues by pharmacological action» (Ukrainian) and «Compleximetry in pharmaceutical analysis» (Ukrainian).
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§   https://scholar.google.com.ua/citations?user=zhFSDuIAAAAJ&hl=uk
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§   https://publons.com/researcher/3167984/serhii-kovalenko/
§   https://orcid.org/0000-0001-8017-9108
§   https://www.researchgate.net/profile/Sergiy_Kovalenko
SCOPUS Preview
Kovalenko, Serhii
Author ID: 55423997600
Documents: 68
Citations: 345
h-index: 11
Co-authors: 134
Subject area: Chemistry | Pharmacology, Toxicology and Pharmaceutics | Biochemistry, Genetics and Molecular Biology | Chemical Engineering | Medicine | Materials Science | Environmental Science | Engineering.
 
Scientific interest
Pharmaceutical, medicinal and organic chemistrty, drug design, synthesis of heterocyclic compounds as potential anticancer, anti-inflammatory, antiviral, antituberculosis, antifungal and antimicrobial drugs.
Purposeful search of biologically active compounds among heterocyclic compounds (tetrazoles, triazoles, imidazoles, quinazolines, pteridines and their condensed analogues), development and creation of drugs based on them. Cooperation with biologists and pharmacologists in terms of finding promising drugs with anti-ischemic, anti-inflammatory, hepatoprotective, antitumor, antimicrobial action. Participation in the development of original drugs used in medical practice. Based on the results of scientific research, he has developed a number of potential biologically active substances that are undergoing in-depth research.
 
Funder research projects
Directed search for anti-inflammatory agents among condensed and spiro-condensed quinazoline derivatives" (№ registration 0118U004370). Kuiv, Ukraine; 2018-2020.
 
Publications (Scopus)
·       S. Kovalenko, I. Belenichev, V. Nikitin, A. Karpenko (2003). Search for substances with antioxidant and antiamnestic activities among 2-substituted 4-(3H)-quinazolones. Acta Poloniae – Drug Research. 60(4): 275-279.
V. Karpenko, S. I. Kovalenko, S. V.Shishkina, O.V. Shishkin (2006). An Efficient and Convenient Synthesis of 2-Thio-[1,2,4]triazolo[1,5-c]quinazoline and its Derivatives. Monatshefte fur Chemie - Chemical Monthly. 137(12): Р.1543-1549.
·       O.V. Karpenko,, S.I. Kovalenko, O.O. Chekotylo, S.V. Shyshkyna  (2007). A new one-step synthesis of [1,2,4]triazino[2,3-c]quinazolines. HETEROCYCLES. 71(3): 619-626..
·       S.I. Kovalenko, A.V. Karpenko, O.V. Krivoshey, S.V. Shishkina, O.V. Shishkin (2007).Novel Method for the Synthesis of [1,2,4]Triazino[4,3-c]quinazoline System. Synthetic Communications. 37: 3719-3727.
·       L.N. Antypenko, A.V. Karpenko, S.I. Kovalenko, A.M. Katsev, E.Z. Komarovska-Porokhnyavetsc, V.P.Novikov, A.A. Chekotilo (2009). Synthesis of New 2-Thio-[1,2,4]triazolo[1,5-c]quinazoline Derivatives and Its Antimicrobial Activity. Chem. Pharm. Bull. 57(6): 580-585.
·       A.V. Karpenko, S.I. Kovalenko, O.V. Shishkin (2009). Synthesis of spiro-fused (C5)-pyrazolino-(C6)-triazinones, a new heterocyclic system. Tetrahedron. 65(31): 5964-5972.
L.N. Antypenko, A.V. Karpenko, S.I. Kovalenko, A.M. Katsev, E.Z. Komarovska-Porokhnyavets, V.P. Novikov (2009). Synthesis, сytotoxicity by bioluminescence inhibition, antibacterial and antifungal activity of ([1,2,4]triazolo[1,5-c]quinazolin-2-ylthio)carboxylic acid amides. Arch. Pharm. Chem. Life Sci. 342: 651-662.
S.I. Kovalenko, I.F. Belenichev, V.V. Galitsa, O.V. Krivoshey 2010. Synthesis of 2-(3,4-dihydro-3-oxo-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid derivatives as potential antioxidants in nitrosative stress model. Pharmacia. 58(2): 145-157.
Voskoboynik A.Yu., Berest G.G., Skorina D. Yu., Karpenko A.V., Kovalenko S.I. (2011). Synthesis of 6-R-3-(2-aminophenyl)-4Н-[1,2,4]thriazin-5-ones: resources and limitations. Chemistry & Chemical Technology. 5(2):129-132.
G.G. Berest, A.Yu. Voskoboynik, S.I. Kovalenko, A.M. Antypenko, I.S. Nosulenko, A.M. Katsev, A.S. Shandrovskaya(2011).Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides. European Journal of Medicinal Chemistry. 46(12): 6066-6074.
·       G.G. Berest, O.Yu. Voskoboynik, S.I. Kovalenko, I.S. Nosulenko, L.M. Antypenko, O.M. Antypenko, V.M. Shvets, A.M. Katsev (2012). Synthesis of new 6-{[w-(dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and evaluation of their anticancer and antimicrobial activities. Sci. Pharm. 80(1): 37-65. doi:10.3797/scipharm.1111-15.
S.I. Kovalenko, I.S. Nosulenko, A.Yu. Voskoboynik, G.G. Berest, L.M. Antypenko, A.N. Antypenko, A.M. Katsev (2012). N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecules. Synthesis, physicochemical properties, cytotoxicity research by bioluminescence inhibition, anticancer activity. Sci. Pharm. 80: 837–865. doi:10.3797/scipharm.1208-07.
·       L. M. Antypenko, O. M. Antypenko, S. I. Kovalenko, O. M. Achkasova (2013).Design and Evaluation of Novel Antimicrobial And Anticancer Agents Among Tetrazolo[1,5-c]Quina­zolin-5-Thion S-Derivatives.Sci. Pharm. 81(1): 15–42.
·       S I. Kovalenko, I.S. Nosulenko, A.Yu. Voskoboynik, G.G. Berest, L.M. Antypenko, A.N. Antypenko, A.M. Katsev (2013). Novel N-aryl(alkaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino­[2,3-c]quinazoline-6-yl)thio]acetamides: synthesis, cytotoxicity, anticancer activity, compare analysis and docking. Medicinal Chemistry Research. 22(6): 2610-2632
·       S. I. Kovalenko, L. M. Antypenko, A. K. Bilyi, S. V. Kholodnyak, O. V. Karpenko, O. M. Antypenko, N. S. Mykhaylova, T. I. Los’, O. S. Kоlоmоеts’ (2013).Synthesis and anticancer activity of 2-аlkyl(alkaryl-, aryl-, heteryl-)-[1,2,4]triazolo[1,5-c]quinazolines.Sci. Pharm. .81(2): P. 359–391.
·       T.Yu. Sergeieva, O.Yu. Voskoboynik, S.I. Okovytyy, S.I. Kovalenko, Sv.V. Shishkina, O.V. Shishkin, J. Leszczynski (2014). Hydrazinolysis of 3‑R‑[1,2,4]Triazino[2,3-c]quinazolin-2-ones. Synthetic and Theoretical Aspects. J. Phys. Chem. A. 118: 1895−1905 (dx.doi.org/10.1021/jp4052616).
I.S. Nosulenko, O.Yu. Voskoboynik, G.G. Berest, S.L. Safronyuk, S.I. Kovalenko, O.M. Kamyshnyi, N.M. Polishchuk, R.S. Sinyak, A.V.Katsev (2014). Synthesis 3-R-8-R1-9-R2-10-R3-R-6-thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones, its antibacterial and antifungal activity. Sci Pharm. 82: 483–500.
K.Gajda, V.Astaknina, K.Eijsmont, D.Kolomeitsev, S.Kovalenko, B.Zarychta (2015). Synthesis and electronic aspects of tetrahydrobenzothienopyrymidine derivatives. Journal of Molecular Structure. 1083: 137-143.
A.K. Bilyi, L.M. Antypenko, V.V. Ivchuk, O.M. Kamyshnyi, N.M. Polishchuk, S.I. Kovalenko (2015). 2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6Н)-thiones and their S-substituted derivatives: synthesis, spectral data and biological activity. ChemPlusChem. 80: 980-989; DOI: 10.1002 / cplu.201500051R1
·      L.M. Antypenko, S.I. Kovalenko, Y.Yu. Posylkina, Vl.O. Nikitin, N.S. Fedyunina, V.V. Ivchuk (2016). 2-Alkyl(Aryl)-Quinazolin-4(3H)-Thiones, 2-R-(Quinazolin-4(3H)-ylthio)carboxylic Acids And Amides. Synthesis, Molecular Docking And Antimicrobial Properties.Journal of enzyme inhibition and medicinal chemistry. 31(2): 253-265. DOI: 10.3109/14756366.2015.1018243.
O.M. Antypenko, S.I. Kovalenko, O.V. Karpenko (2016). Synthesis and hydrolytic cleavage of tetrazolo[1,5-c]quinazolines. Synthetic Communications. 46(6): 551-555. doi: 10.1080/00397911.2016.1156131.
·       A.Yu. Voskoboynik, D.Yu. Scorina, T.Yu. Sergeieva, S.I. Kovalenko, S.I. Okovytyy, I.V. Omelchenko, O.V. Shishkin (2016). Interaction of 3-(2-Aminophenyl)-6-R1-1,2,4-triazin-5-ones with Acylating Reagents: An Efficient Method for Preparation of 6-Substituted 3-R1-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. J. Het. Chem. 53(3): 776-783.DOI 10.1002/jhet.2120.
Antypenko O., Kovalenko S., Shernova G. (2016).Search compounds with hypoglycemic activity in the series of 1-(2-1H-tetrazol-5-yl)-R-phenyl-)3-R-phenyl(ethyl)ureas and R-tetrazolo[1,5-c]quinazolin-5(6H)-ones. Sci Pharm. 84: 233–254. doi:10.3797/ scipharm.1507-14
·       Voskoboynik O.Yu., Кovalenko S.I., Shishkina Sv.V. (2016). 3-R1-8-R2-10-R3-2H-benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones – novel high electro-deficient heterocyclic compounds with promising anticancer activity. Heterocyclic Communications. 22(3): 137–141; DOI 10.1515/hc-2015-0190.
·       D.O. Kolomieitsev, V.I. Markov, S.A. Varenichenko, V.O. Astakhina, S.I. Kovalenko, A.V. Kharchenko, A.V. Mazepa (2016). Dimroth rearrangement in the synthesis of substituted cyclopenta and cyclohexa[4,5]thieno[2',3':4,5]pyrimido[1,6-b][1,2,4]triazines. Chem. Heterocycl. Compd.. 52(7): 498–502; DOI 10.1007/s10593-016-1915-6.
·      L.М. Antypenko, O.M. Antypenko, S.I Kovalenko, O.V. Karpenko, V.O. Nikitin (2016). Synthesis, anticancer and QSAR studies of 2-alkyl(aryl,hetaryl)-quinazolin-4(3H)-thione's and [1,2,4]triazolo[1,5-c]quinazoline-2-thione's thioderivatives. Helvetica Chimica Acta. 99: 1-11; DOI: 10.1002 / hlca.201600062.
·       O.M. Antypenko, S.I. Kovalenko, Bakhtiyor F. Rasulev, J. Leszczynsk (2016). Synthesis of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, anticancer activity and QSAR modeling. ACTA CHIMICA SLOVENICA. 63: 638-645; doi: 10.17344/acsi.2016.2464.
·      L.M. Antypenko, S.I. Kovalenko, A.M. Katsev, E.Z. Komarovska-Porokhnyavets, V.P. Novikov, N.S. Fedyunina (2015). 1-R-2-([1,2,4]Triazolo[1,5-c]quinazoline-2-ylthio)etanon(ol)s: synthesis, bioluminescence inhibition, molecular docking studies, antibacterial and antifungal activity. Current Computer-Aided Drug Design. 12(1): 29-41; DOI: 10,2174 / 1573409912666160126142236.
·      O. M. Antypenko, L.M. Antypenko, S.I. Kovalenko, A.M. Katsev, O.M. Achkasova (2016). Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents. Arabian Journal of Chemistry. 9: 792-805.(DOI: 10.1016 / j.arabjc.2014.09.009).
·       Sergeieva T; Bilichenko M.; Kholodnyak S.; Monaykina Yu.; Okovytyy S.; Kovalenko S.; Voronkov E.; Leszczynski J. (2016). Origin of Substituent Effect on Tautomeric Behavior of 1,2,4-Triazole Derivatives. Combined Spectroscopic and Theoretical Study. J. Phys. Chem. A. 120: 10116−10122; DOI: 10.1021/acs.jpca.6b08317
·       L. Logoyda, D. Korobko, I. Ivanusa, S. Kovalenko (2017). Development of the methodology of the chromatographic determination of nifedipine in medicines. Asian J. Pharm. Clin. Res. 10(3): 149-152.
·       O.Yu. Voskoboynik, O. S. Kolomoetsch, G.G.Berest, I.S. Nosulenko, Yu.V. Martunenko, S.I. Kovalenko (2017). Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogues. Chem. Heterocycl. Compd.. 53(3): 256–272.
·       O.M. Antypenko, S.V. Kholodnyak, K.P. Schabelnyk, L.M. Antypenko, S.I. Kovalenko (2017). [2-(Azolyl)phenyl]amines: methods of synthesis, cyclocondensations and biological properties. Chem. Heterocycl. Compd. 53(3): 292–309.
·       O.Yu. Voskoboynik, O.S. Kolomoets, S.I. Kovalenko, S.V. Shishkina (2017). [1,2,4]Triazino[2,3-с]quinazolines 1. Methods for the preparation and spectral characteristics of substituted 3-R1-6-R3-6,7-dihydro-2H-[1,2,4]triazino[2,3-с]quinazolin-2-ones. Chem. Heterocycl. Compd.. 53(8): 892–904.
·       O.Yu. Voskoboynik, S.I. Кovalenko, S.I. Okovytyy, S.V. Shishkina (2017). Dimethyl acetylenedicarboxylate in reactions with substituted 3-(2-aminophenyl)-6-phenyl-1,2,4-triazin-5-(2H)-ones: structure and properties of the products. J. Heterocyclic Chem. 54(3): 2038-2042. DOI 10.1002/jhet.2801.
·       O.Yu. Voskoboynik, O.S. Kolomoets, V.A. Palchikov, S.I. Kovalenko, I.F. Belenichev, S.V. Shishkina (2017). [1,2,4]Triazino[2,3-с]quinazolines 2. Synthesis, structure, and anticonvulsant activity of new 3′-R1-spiro[(aza/oxa/thia)cycloalkyl-1(3, 4),6′-[1,2,4]triazino[2,3-c]quinazolin]-2′(7′H)-ones. Chem. Heterocycl. Compd.  53(10): 1134–1147. DOI 10.1007/s10593-017-2184-8
·       O. Kolomoets, О. Voskoboynik, O. Antypenko, G. Berest, I. Nosulenko, V. Palchikov, O. Karpenko, S. Kovalenko. (2017). Desing, synthesis and anti-inflammatory activity of dirivatives 10-R-3-aryl-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones of spiro-fused cyclic frameworks. Acta Chim. Slov. 64(4): 902-910; DOI: 10.17344/acsi.2017.3575.
·       О. Yu. Voskoboynik, O.S. Kolomoetsa, O. M. Antypenko, G. О. Zhernova, I.S. Nosulenko, G.G. Berest, V.M. Shvets, S.I. Kovalenko (2017). Synthesis and hypolipidemic activity of new 6,6-disubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. J. Heterocyclic Chem. 35(1): 318-325. DOI 10.1002/jhet.3054.
·       M. S. Kazunin, O. Yu. Voskoboynik, I.S. Nosulenko, G.G. Berest, T. Sergeieva, S.Okovytyy, O.V. Karpenko, B.O. Priymenko, S.I. Kovalenko (2018). Synthesis, tautomerism and antiradical activity of 1-methyl-6-(2-(aryl-(hetaryl-))-2-oxoethyl)pteridine-2,4,7(1H, 3H, 6H)-triones. J. Heterocyclic Chem. 4: 1033-1041; DOI: 10.1002/jhet.3135.
·       Voskoboynik O.Yu., Shishkina S.V., Kovalenko S.I. (2018). [1,2,4]Triazino[2,3-c]quina­zolines 3. Reaction of 3- (2-aminophenyl) -6-R-1,2,4-triazin-5 (2H)-ones with aryliso­(thio)cyanates: structure and anticancer activity of products. Chem. Heterocycl. Compd. 54(7): 717-728. DOI: https://doi.org/10.1007/s10593-018-2338-3.
·       Antypenko L,, Meyer F., Kholodnyak O., Jirásková T., Troianova A., Buhaiova V., Cao Surui, Sadykova Z., Kovalenko S., Garbe L., Steffens K. (2018). Novel acyl thiourea derivatives: synthesis, antifungal activity, gene toxicity, drug-like screening and molecular docking. Archive der Pharmazie, 1–14. https://doi.org/10.1002/ardp.201800275.
·       Yu. V. Martynenko, O. M. Antypenko, О. A. Brazhko, I. B. Labenska, S. I. Kovalenko (2019). Directed search of biologically active compounds among hydrogenated isoindolylalkyl(alkaryl-, aryl-)carboxylic acids with quinazoline fragment that influence on the carbohydrate metabolism: design, synthesis and modification. Acta Chim. Slov. 66: 145-154. DOI: 10.17344/acsi.2018.4731.
·       Yu. Martynenko, O. Antypenko, I. Nosulenko, G. Berest, S. Kovalenko (2019). Directed search of anti-inflammatory agents among (3H-quinazoline-4-ylidene)hydrazides of N-protected amino acids and their heterocyclization products. Anti-Inflammatory & Anti-Allergy Agents in Med. Chem. 19(1):. 60-71. DOI: 10.2174/1871523018666190115092215.
·       L. Logoyda, S. Kovalenko, Ahmed M. Abdel-Medied, I. Zhulkevych, I. Drapak, I. Demchuk, O. Netsyuk(2019).HPLC method development for the analysis of bisoprolol in combined dosage form containing bisoprolol and enalapril and vitro dissolution studied International Journal of Applied Pharmaceutics. (Int J App Pharm). 11(3): 186-194. DOI: http://dx.doi.org/10.22159/ijap.2019v11i3.32391
·           O. Yu. Voskoboynik, O. S. Kolomoets, I. S. Nosulenko, G. G. Berest, Bilyi А.К.,O. V. Karpenko, I. F. Belenichev, S. I. Kovalenko (2019). Synthesis, modification and anticonvulsant activity of 3'-R-spiro[indoline-3,6'-[1,2,4]triazino[2,3-c]quinazolin]-2,2'(7'H)-diones dirivatives. J. Heterocyclic Chem. 56(5): 1605-1612. DOI: 10.1002 / jhet.3541.
·       M.S. Kazunin, A. Yu. Voskoboinik, O. M. Shatalova, L. N. Maloshtan, S. I. Kovalenko (2019). Amides of substituted 3-(pteridin-6-yl)propanoic acids: synthesis, spectral characteristics and cytotoxic activity. Chem. Heterocycl. Compd. 55(4/5): 408–415.
·       Antypenko L., Sadykova Z., Shabelnyk K., Hassan F, Steffens Karl, Kovalenko S., Meyer Vera, Garbe Leif. (2019). Synthesis and mode of action studies of novel {2‐(3‐R‐1H‐1,2,4‐triazol‐5‐yl)phenyl}amines to combat pathogenic fungi. Archive der Pharmazie. e1900092. https://doi.org/10.1002/ardp.201900092.
·       Drapak, B. Zimenkovsky, L. Perekhoda, S. Kovalenko, L. Logoyda (2019). LC-MS/MS method development and validation for the determination of cardiazol in human plasma. International Journal of Applied Pharmaceutics (Int J App Pharm). 11(4): 380-385. DOI: http://dx.doi.org/10.22159/ijap.2019v11i4.33482.
·       Drapak, B. Zimenkovsky, L. Perekhoda, S. Kovalenko, L. Logoyda (2019). Development and validation of LC-MS/MS method for estimation of urocarb in human plasma. International Journal of Applied Pharmaceutics (Int J App Pharm). 11(5): 125-130. DOI:  https://doi.org/10.22159/ijap.2019v11i5.33873.
·       M.S. Kazunin, O.Yu. Voskoboynik, I.S. Nosulenko, G.G. Berest, S.V. Kholodnyak, B.O. Pryymenko, S.I. Kovalenko(2019).Synthesis, antiradical and antimicrobial activity of new pteridine-2,4,7-trione derivatives. J. Heterocyclic Chem. 1-13. DOI: 10.1002/jhet.3774.
·       V. Stavytskyi, O. Voskoboinik, O. Antypenko, N. Krasovska, K. Shabelnyk, I. Konovalova, S. Shishkyna, S. Kholodniak, S. Kovalenko. (2020). Tandem heterocyclization of 2-(azolyl-(azinyl-))anilines as an efficient method for preparation of substituted pyrrolo[1,2-a]azolo-(azino-)[c]quinazolines. J. Heterocyclic Chem. 57(3): 1249-1260. https://doi.org/10.1002/jhet.3862.
·       V. Stavytskyi, О. Voskoboinik, М. Kazunin, I. Nosulenko, S. Shishkina, S. Kovalenko (2020). Substituted pyrrolo[1,2-a][1,2,4]triazolo-([1,2,4]triazino-)[c]quinazoline-4a(5a)-propanoic acids: synthesis, spectral characteristics and anti-inflammatory activity. Voprosy khimii i khimicheskoi tekhnologii. 1: 61-70. DOI: 10.32434/0321-4095-2020-128-1-61-70. (Ukraine).
·       Logoyda L., Kovalenkо S., Gaafar M., Abdel-Megied A. M., Elbarbry F. A. (2020).A validated LC-MS/MS method for the quantification of amlodipine, bisoprolol, enalapril and enalaprilat-Application to pharmacokinetic study in healthy volunteers. Microchemical Journal, 155, 104700. doi:10.1016/j.microc.2020.104700.
·       M. S. Kazunin, O. Yu. Voskoboynik, S. V. Shishkina, O. M. Antypenko, S. I. Kovalenko. (2020). A Simple and Convenient Method for the Synthesis of 1-Methyl-7-arylfuro[3,2-g]­pteridine-2,4(1H,3H)-diones and Their Substituted Derivatives. Acta Chim. Slov. 67: 586–593.. DOI: 10.17344/acsi.2019.5601.
·       O.Yu.Voskoboinik, V.V. Stavytskyi, O.M. Antypenko, M.S. Kazunin, D.V. Kravtsov, S.V. Shishkina S.I. Kovalenko. (2020). Synthesis and structure of pyrido[1,2-a]quinazoline condensed derivatives. Synthetic Communications. 50(13), 2043–2051. https://doi.org/10.1080/00397911.2020.1762223.
·       O.V. Kholodniak, M.S. Kazunin, F. Meyer, S. I. Kovalenko, K. G. Steffens. (2020). Novel N-cycloalkylcarbonyl-N¢-aryl-thioureas: Synthesis, Design, Antifungal Activity and Gene Toxicity. Chemistry and Biodiversity, 17, е2000212. DOI: 10.1002/cbdv.202000212.
·       V. Stavytskyi, O. Antypenko, I. Nosylenko, G. Berest, O. Voskoboinik, S. Kovalenko (2020).Substituted 3-R-2,8-Dioxo-7,8-dihydro-2H-pyrrolo[1,2-a][1,2,4]triazino[2,3-c]quinazoline-5a(6H)carboxylic Acids and Their Salts – a Promising Class of Anti-inflammatory Agents. Anti-Inflammatory & Anti-Allergy Agents in Med. Chem. DOI: 10.2174/1871523019666200505073232
·       Martynenko Yu. V., Berest G. G., Bukhtiayrova N. V., Belenichev I. F., Voskoboinik O. Yu., Kovalenko S. I. (2020). 2-[(3-Aminoalkyl-(alkaryl-,aryl-))-1H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity. Turk. J. Chem, doi:10.3906/kim-2002-24.
 
LANGUAGES
Ukrainian, Russian,– native; fluent; English – with a dictionary.
 
 aporizhzhia State Medical University
Mayakovsky Av. 26, 69035, Zaporizhzhia, Ukraine
Phone: +38(061)2246469; +38(061)2398586 (Department); +38(097)6876889
Fax: +38(061)2336007
 
E-mail: kovalenkosergiy@gmail.com
 
Scientific and educational degree      Dr. Prof.
 
Habilitation, DSc   2000, Zaporizhzhia State Medical University, Ukraine, Department of Pharmaceutical Chemistry. Thesis title: «Synthesis, transformation, physicochemical and biological properties of quinazolone-4 and 4-aminoquinazolines». Supervisor: prof. Ivan Mazur.
PhD                      1991, Zaporizhzhia State Medical University, Ukraine, Department of Pharmaceutical Chemistry. Thesis title: «Synthesis, physicochemical and biological properties 1,4-derivative quinazolines». Supervisor: prof. Ivan Mazur.
MSc                     1985, Zaporizhzhia State Medical University, Ukraine, Department of Pharmaceutical Chemistry. Thesis title: Synthesis and biological properties new 4-arylaminoquinazolines». Supervisor: prof. Ivan Mazur, assoc. prof. Raisa Sunyak.
 
Sciences field and Area of Science
Medical and Health Sciences, Pharmacy – M 003
 
Professional career
 
Since 2012      Head Department of the Organic and Bioorganic Chemistry at Zaporizhzhia State Medical University
2004-2012      Professor of the Department of Pharmaceutical Chemistry at Zaporizhzhia State Medical University
2000-2004          Assoc. prof (docent) of the Department of Pharmaceutical Chemistry at Zaporizhzhia State Medical University
1998-2000      Senior Lecturer of the Department of Pharmaceutical Chemistry at Zaporizhia State Medical University.
1989-1998      Research assistant of the Department of Pharmaceutical Chemistry at Zaporizhia State Medical University.
1988-1989      Senior laboratory assistant of the Department of Pharmaceutical Chemistry at Zaporizhia State Medical University.
185-1988        Head of pharmacy-shop Novoukrainka town, Kirovohrad region, Ukraine
 
Professional memberships
Ø  Member of the Exert Council of the Ministry of Education of Ukraine on Theoretical and Preventive Medicine and Pharmacy
Ø  Member of the Academic Council at Zaporizhia State Medical University
Ø  Deputy Chairman of the Specialized Academic Council for the Defense of Dissertations D.17.600.03 at Zaporizhia State Medical University.
Ø  Member of the commission for attestation of pharmaceutical personnel of Zaporizhia region
 
International Activity
Ø  Collaboration with National Cancer Institute, NIAID, Southern Research Institute, NINDS (NIH, Bethesda, Maryland, USA)
Ø  Visiting Professor of on Technical University of Liberec (Institute for Nanomaterials, Advanced Technologies and Innovation – 2012
Ø  Visiting Professor of on Neubrandenburg University of Applied Sciences – 2019
 
Editorial & Advisory Boards
«Zaporozhye medical journal» (Ukraine), «Journal of Organic and Pharmaceutical Chemistry» (Ukraine), «Pharmacon» (Ukraine), «Clinical Pharmacy, Pharmacotherapy and Medical Standardization» (Ukraine), «Current issues in pharmacy and medicine: science and practice» (Ukraine),
 
Supervisions of dissertations
Krasovska N.I. PhD (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Carboxyl-containing [1,2,4]triazolo[1,5-c]quinazolines and their functional derivatives: synthesis, physicochemical properties and anti-inflammatory activity»
Kholodniak O.V. PhD (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «N-(R-Carbamothioyl)cycloalkylcarboxamides: synthesis, modification, physicochemical and biological properties»
Stavytskyi V.V. (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Pyrrolo(pyrido)[1,2-a]triazolo(triazino)[c]quinazolines: synthesis, modification, physicochemical and biological properties»
Shabelnyk K.Р. Dsc (in progress), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 5-substituted 2-R-[1,2,4] triazolo[c] - and 2-R-5,6-dihydro- [1,2,4] triazolo[c]quinazolines»;
Voskoboynik O. Yu. Dsc (2019), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «[1,2,4]Triazino[c]quinazolines: synthesis, transformations, physicochemical and biological properties»
Logoida L.S. Dsc (2019),Ternopil National Medical University, Ternopil, Ukraine. Thesis title: «Scientific and theoretical substantiation of bioanalytical research and standardization of antihypertensive drugs using chromatographic methods»;
Martynenko Yu.V. PhD (2019), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «{([1,2,4]Triazolo[1,5-c]quinazolin-2-yl)alkyl-(alkaryl-, alkhetaryl-, aryl-)}amines and their imides: synthesis, chemical modification, physico-chemical and biological properties of the synthesized compounds»;
Kolomoets O.S. PhD (2018), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 6-mono- and 6,6-disubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-оnes»;
Antypenko O.M. PhD (2016), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Tetrazolо[1,5-c]quinazoline(6H)-5-ones(thiones): synthesis, functionalization, physico-chemical and biological properties»;
Kholodnyak S.V. PhD (2016), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «[(3-Аryl-1H-1,2,4-triazol)phenyl]amines: synthesis, chemical modification, physicochemical and biological properties of the synthesized compounds»;
Nosulenko I. S. PhD (2015), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physico-chemical and biological properties of 2-[(3-R-2-оxo-2Н-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetic acids and then substituted»;
Skorina D.Yu. PhD (2015), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties  (3-R-2-oxo-2H-[1,2,4]­triazino[2,3-c]quinazolin-6-yl)carbonic acids and their derivatives»
Biliy A. K. PhD (2014), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, transformation, physico-chemical and biological properties of 5-substituted 2-heteryl[1,2,4]triazolo[с]quinazolines»;
Voloschina V.A. PhD (2011), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physico-chemical and biological properties of substituted for 1,2,4-triazoles and its condensed derivates»;
Аvramenko А.І. PhD (2011), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Directed search for hepatoprotectors with antioxidant mechanism of action among 4-thioquinazoline derivatives based on the laws of the relationship "structure-action»
Аntypenko L.M. PhD (2010), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties S-derivatives of 2-thio[1,2,4]triazolo[1,5-c]quinazolines»;
Krivoshey O.V. PhD (2009), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of derivatives (6-R-3-oxo-2,3-dihydro-4H-[1,2,4]triazino[4,3-c]quinazoline-4-yl)acetic acid»
Voskoboynik O. Yu. PhD (2008), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, transformation, physicochemical and biological properties of [{2-R- (3H-quinazolin-4-ylidene}hydrazone]carboxylic acids»;
Karpenko O.V.  PhD (2007), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis of annulus heterocyclic compounds of 4-hydrazinoquinazoline derivatives and their biological activity»;
Nikitin V.A. PhD (2007), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 2-R-quinazolin-4-one (thione) derivatives»;
Shabelnyk K.P. PhD (2007), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of amides (6-R-4-oxo-4H-quinazolin-3-yl)alkyl(aryl-)carboxylic acids»;
Nesterova N.O. PhD (2005), Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. Thesis title: «Synthesis, physicochemical and biological properties of 4-hydrazinoquinazoline derivatives».
 
publucations
Authors of 318 scientific papers (68 Scopus), 61 patents, 423 conference and workshops communications, co-autors of the book «Antimalarial drugs. Quinine and its analogues by pharmacological action» (Ukrainian) and «Compleximetry in pharmaceutical analysis» (Ukrainian).
§   https://www.scopus.com/authid/detail.uri?authorId=55423997600
§   https://scholar.google.com.ua/citations?user=zhFSDuIAAAAJ&hl=uk
§   https://www.mendeley.com/authors/55423997600/
§   https://publons.com/researcher/3167984/serhii-kovalenko/
§   https://orcid.org/0000-0001-8017-9108
§   https://www.researchgate.net/profile/Sergiy_Kovalenko
SCOPUS Preview
Kovalenko, Serhii
Author ID: 55423997600
Documents: 68
Citations: 345
h-index: 11
Co-authors: 134
Subject area: Chemistry | Pharmacology, Toxicology and Pharmaceutics | Biochemistry, Genetics and Molecular Biology | Chemical Engineering | Medicine | Materials Science | Environmental Science | Engineering.
 
Scientific interest
Pharmaceutical, medicinal and organic chemistrty, drug design, synthesis of heterocyclic compounds as potential anticancer, anti-inflammatory, antiviral, antituberculosis, antifungal and antimicrobial drugs.
Purposeful search of biologically active compounds among heterocyclic compounds (tetrazoles, triazoles, imidazoles, quinazolines, pteridines and their condensed analogues), development and creation of drugs based on them. Cooperation with biologists and pharmacologists in terms of finding promising drugs with anti-ischemic, anti-inflammatory, hepatoprotective, antitumor, antimicrobial action. Participation in the development of original drugs used in medical practice. Based on the results of scientific research, he has developed a number of potential biologically active substances that are undergoing in-depth research.
 
Funder research projects
Directed search for anti-inflammatory agents among condensed and spiro-condensed quinazoline derivatives" (№ registration 0118U004370). Kuiv, Ukraine; 2018-2020.
 
Publications (Scopus)
·       S. Kovalenko, I. Belenichev, V. Nikitin, A. Karpenko (2003). Search for substances with antioxidant and antiamnestic activities among 2-substituted 4-(3H)-quinazolones. Acta Poloniae – Drug Research. 60(4): 275-279.
V. Karpenko, S. I. Kovalenko, S. V.Shishkina, O.V. Shishkin (2006). An Efficient and Convenient Synthesis of 2-Thio-[1,2,4]triazolo[1,5-c]quinazoline and its Derivatives. Monatshefte fur Chemie - Chemical Monthly. 137(12): Р.1543-1549.
·       O.V. Karpenko,, S.I. Kovalenko, O.O. Chekotylo, S.V. Shyshkyna  (2007). A new one-step synthesis of [1,2,4]triazino[2,3-c]quinazolines. HETEROCYCLES. 71(3): 619-626..
·       S.I. Kovalenko, A.V. Karpenko, O.V. Krivoshey, S.V. Shishkina, O.V. Shishkin (2007).Novel Method for the Synthesis of [1,2,4]Triazino[4,3-c]quinazoline System. Synthetic Communications. 37: 3719-3727.
·       L.N. Antypenko, A.V. Karpenko, S.I. Kovalenko, A.M. Katsev, E.Z. Komarovska-Porokhnyavetsc, V.P.Novikov, A.A. Chekotilo (2009). Synthesis of New 2-Thio-[1,2,4]triazolo[1,5-c]quinazoline Derivatives and Its Antimicrobial Activity. Chem. Pharm. Bull. 57(6): 580-585.
·       A.V. Karpenko, S.I. Kovalenko, O.V. Shishkin (2009). Synthesis of spiro-fused (C5)-pyrazolino-(C6)-triazinones, a new heterocyclic system. Tetrahedron. 65(31): 5964-5972.
L.N. Antypenko, A.V. Karpenko, S.I. Kovalenko, A.M. Katsev, E.Z. Komarovska-Porokhnyavets, V.P. Novikov (2009). Synthesis, сytotoxicity by bioluminescence inhibition, antibacterial and antifungal activity of ([1,2,4]triazolo[1,5-c]quinazolin-2-ylthio)carboxylic acid amides. Arch. Pharm. Chem. Life Sci. 342: 651-662.
S.I. Kovalenko, I.F. Belenichev, V.V. Galitsa, O.V. Krivoshey 2010. Synthesis of 2-(3,4-dihydro-3-oxo-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid derivatives as potential antioxidants in nitrosative stress model. Pharmacia. 58(2): 145-157.
Voskoboynik A.Yu., Berest G.G., Skorina D. Yu., Karpenko A.V., Kovalenko S.I. (2011). Synthesis of 6-R-3-(2-aminophenyl)-4Н-[1,2,4]thriazin-5-ones: resources and limitations. Chemistry & Chemical Technology. 5(2):129-132.
G.G. Berest, A.Yu. Voskoboynik, S.I. Kovalenko, A.M. Antypenko, I.S. Nosulenko, A.M. Katsev, A.S. Shandrovskaya(2011).Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides. European Journal of Medicinal Chemistry. 46(12): 6066-6074.
·       G.G. Berest, O.Yu. Voskoboynik, S.I. Kovalenko, I.S. Nosulenko, L.M. Antypenko, O.M. Antypenko, V.M. Shvets, A.M. Katsev (2012). Synthesis of new 6-{[w-(dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and evaluation of their anticancer and antimicrobial activities. Sci. Pharm. 80(1): 37-65. doi:10.3797/scipharm.1111-15.
S.I. Kovalenko, I.S. Nosulenko, A.Yu. Voskoboynik, G.G. Berest, L.M. Antypenko, A.N. Antypenko, A.M. Katsev (2012). N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecules. Synthesis, physicochemical properties, cytotoxicity research by bioluminescence inhibition, anticancer activity. Sci. Pharm. 80: 837–865. doi:10.3797/scipharm.1208-07.
·       L. M. Antypenko, O. M. Antypenko, S. I. Kovalenko, O. M. Achkasova (2013).Design and Evaluation of Novel Antimicrobial And Anticancer Agents Among Tetrazolo[1,5-c]Quina­zolin-5-Thion S-Derivatives.Sci. Pharm. 81(1): 15–42.
·       S I. Kovalenko, I.S. Nosulenko, A.Yu. Voskoboynik, G.G. Berest, L.M. Antypenko, A.N. Antypenko, A.M. Katsev (2013). Novel N-aryl(alkaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino­[2,3-c]quinazoline-6-yl)thio]acetamides: synthesis, cytotoxicity, anticancer activity, compare analysis and docking. Medicinal Chemistry Research. 22(6): 2610-2632
·       S. I. Kovalenko, L. M. Antypenko, A. K. Bilyi, S. V. Kholodnyak, O. V. Karpenko, O. M. Antypenko, N. S. Mykhaylova, T. I. Los’, O. S. Kоlоmоеts’ (2013).Synthesis and anticancer activity of 2-аlkyl(alkaryl-, aryl-, heteryl-)-[1,2,4]triazolo[1,5-c]quinazolines.Sci. Pharm. .81(2): P. 359–391.
·       T.Yu. Sergeieva, O.Yu. Voskoboynik, S.I. Okovytyy, S.I. Kovalenko, Sv.V. Shishkina, O.V. Shishkin, J. Leszczynski (2014). Hydrazinolysis of 3‑R‑[1,2,4]Triazino[2,3-c]quinazolin-2-ones. Synthetic and Theoretical Aspects. J. Phys. Chem. A. 118: 1895−1905 (dx.doi.org/10.1021/jp4052616).
I.S. Nosulenko, O.Yu. Voskoboynik, G.G. Berest, S.L. Safronyuk, S.I. Kovalenko, O.M. Kamyshnyi, N.M. Polishchuk, R.S. Sinyak, A.V.Katsev (2014). Synthesis 3-R-8-R1-9-R2-10-R3-R-6-thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones, its antibacterial and antifungal activity. Sci Pharm. 82: 483–500.
K.Gajda, V.Astaknina, K.Eijsmont, D.Kolomeitsev, S.Kovalenko, B.Zarychta (2015). Synthesis and electronic aspects of tetrahydrobenzothienopyrymidine derivatives. Journal of Molecular Structure. 1083: 137-143.
A.K. Bilyi, L.M. Antypenko, V.V. Ivchuk, O.M. Kamyshnyi, N.M. Polishchuk, S.I. Kovalenko (2015). 2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6Н)-thiones and their S-substituted derivatives: synthesis, spectral data and biological activity. ChemPlusChem. 80: 980-989; DOI: 10.1002 / cplu.201500051R1
·      L.M. Antypenko, S.I. Kovalenko, Y.Yu. Posylkina, Vl.O. Nikitin, N.S. Fedyunina, V.V. Ivchuk (2016). 2-Alkyl(Aryl)-Quinazolin-4(3H)-Thiones, 2-R-(Quinazolin-4(3H)-ylthio)carboxylic Acids And Amides. Synthesis, Molecular Docking And Antimicrobial Properties.Journal of enzyme inhibition and medicinal chemistry. 31(2): 253-265. DOI: 10.3109/14756366.2015.1018243.
O.M. Antypenko, S.I. Kovalenko, O.V. Karpenko (2016). Synthesis and hydrolytic cleavage of tetrazolo[1,5-c]quinazolines. Synthetic Communications. 46(6): 551-555. doi: 10.1080/00397911.2016.1156131.
·       A.Yu. Voskoboynik, D.Yu. Scorina, T.Yu. Sergeieva, S.I. Kovalenko, S.I. Okovytyy, I.V. Omelchenko, O.V. Shishkin (2016). Interaction of 3-(2-Aminophenyl)-6-R1-1,2,4-triazin-5-ones with Acylating Reagents: An Efficient Method for Preparation of 6-Substituted 3-R1-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. J. Het. Chem. 53(3): 776-783.DOI 10.1002/jhet.2120. 
Antypenko O., Kovalenko S., Shernova G. (2016).Search compounds with hypoglycemic activity in the series of 1-(2-1H-tetrazol-5-yl)-R-phenyl-)3-R-phenyl(ethyl)ureas and R-tetrazolo[1,5-c]quinazolin-5(6H)-ones. Sci Pharm. 84: 233–254. doi:10.3797/ scipharm.1507-14
·       Voskoboynik O.Yu., Кovalenko S.I., Shishkina Sv.V. (2016). 3-R1-8-R2-10-R3-2H-benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones – novel high electro-deficient heterocyclic compounds with promising anticancer activity. Heterocyclic Communications. 22(3): 137–141; DOI 10.1515/hc-2015-0190.
·       D.O. Kolomieitsev, V.I. Markov, S.A. Varenichenko, V.O. Astakhina, S.I. Kovalenko, A.V. Kharchenko, A.V. Mazepa (2016). Dimroth rearrangement in the synthesis of substituted cyclopenta and cyclohexa[4,5]thieno[2',3':4,5]pyrimido[1,6-b][1,2,4]triazines. Chem. Heterocycl. Compd.. 52(7): 498–502; DOI 10.1007/s10593-016-1915-6.
·      L.М. Antypenko, O.M. Antypenko, S.I Kovalenko, O.V. Karpenko, V.O. Nikitin (2016). Synthesis, anticancer and QSAR studies of 2-alkyl(aryl,hetaryl)-quinazolin-4(3H)-thione's and [1,2,4]triazolo[1,5-c]quinazoline-2-thione's thioderivatives. Helvetica Chimica Acta. 99: 1-11; DOI: 10.1002 / hlca.201600062.
·       O.M. Antypenko, S.I. Kovalenko, Bakhtiyor F. Rasulev, J. Leszczynsk (2016). Synthesis of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, anticancer activity and QSAR modeling. ACTA CHIMICA SLOVENICA. 63: 638-645; doi: 10.17344/acsi.2016.2464.
·      L.M. Antypenko, S.I. Kovalenko, A.M. Katsev, E.Z. Komarovska-Porokhnyavets, V.P. Novikov, N.S. Fedyunina (2015). 1-R-2-([1,2,4]Triazolo[1,5-c]quinazoline-2-ylthio)etanon(ol)s: synthesis, bioluminescence inhibition, molecular docking studies, antibacterial and antifungal activity. Current Computer-Aided Drug Design. 12(1): 29-41; DOI: 10,2174 / 1573409912666160126142236.
·      O. M. Antypenko, L.M. Antypenko, S.I. Kovalenko, A.M. Katsev, O.M. Achkasova (2016). Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents. Arabian Journal of Chemistry. 9: 792-805.(DOI: 10.1016 / j.arabjc.2014.09.009).
·       Sergeieva T; Bilichenko M.; Kholodnyak S.; Monaykina Yu.; Okovytyy S.; Kovalenko S.; Voronkov E.; Leszczynski J. (2016). Origin of Substituent Effect on Tautomeric Behavior of 1,2,4-Triazole Derivatives. Combined Spectroscopic and Theoretical Study. J. Phys. Chem. A. 120: 10116−10122; DOI: 10.1021/acs.jpca.6b08317
·       L. Logoyda, D. Korobko, I. Ivanusa, S. Kovalenko (2017). Development of the methodology of the chromatographic determination of nifedipine in medicines. Asian J. Pharm. Clin. Res. 10(3): 149-152.
·       O.Yu. Voskoboynik, O. S. Kolomoetsch, G.G.Berest, I.S. Nosulenko, Yu.V. Martunenko, S.I. Kovalenko (2017). Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogues. Chem. Heterocycl. Compd.. 53(3): 256–272.
·       O.M. Antypenko, S.V. Kholodnyak, K.P. Schabelnyk, L.M. Antypenko, S.I. Kovalenko (2017). [2-(Azolyl)phenyl]amines: methods of synthesis, cyclocondensations and biological properties. Chem. Heterocycl. Compd. 53(3): 292–309.
·       O.Yu. Voskoboynik, O.S. Kolomoets, S.I. Kovalenko, S.V. Shishkina (2017). [1,2,4]Triazino[2,3-с]quinazolines 1. Methods for the preparation and spectral characteristics of substituted 3-R1-6-R3-6,7-dihydro-2H-[1,2,4]triazino[2,3-с]quinazolin-2-ones. Chem. Heterocycl. Compd.. 53(8): 892–904.
·       O.Yu. Voskoboynik, S.I. Кovalenko, S.I. Okovytyy, S.V. Shishkina (2017). Dimethyl acetylenedicarboxylate in reactions with substituted 3-(2-aminophenyl)-6-phenyl-1,2,4-triazin-5-(2H)-ones: structure and properties of the products. J. Heterocyclic Chem. 54(3): 2038-2042. DOI 10.1002/jhet.2801.
·       O.Yu. Voskoboynik, O.S. Kolomoets, V.A. Palchikov, S.I. Kovalenko, I.F. Belenichev, S.V. Shishkina (2017). [1,2,4]Triazino[2,3-с]quinazolines 2. Synthesis, structure, and anticonvulsant activity of new 3′-R1-spiro[(aza/oxa/thia)cycloalkyl-1(3, 4),6′-[1,2,4]triazino[2,3-c]quinazolin]-2′(7′H)-ones. Chem. Heterocycl. Compd.  53(10): 1134–1147. DOI 10.1007/s10593-017-2184-8
·       O. Kolomoets, О. Voskoboynik, O. Antypenko, G. Berest, I. Nosulenko, V. Palchikov, O. Karpenko, S. Kovalenko. (2017). Desing, synthesis and anti-inflammatory activity of dirivatives 10-R-3-aryl-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones of spiro-fused cyclic frameworks. Acta Chim. Slov. 64(4): 902-910; DOI: 10.17344/acsi.2017.3575.
·       О. Yu. Voskoboynik, O.S. Kolomoetsa, O. M. Antypenko, G. О. Zhernova, I.S. Nosulenko, G.G. Berest, V.M. Shvets, S.I. Kovalenko (2017). Synthesis and hypolipidemic activity of new 6,6-disubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. J. Heterocyclic Chem. 35(1): 318-325. DOI 10.1002/jhet.3054.
·       M. S. Kazunin, O. Yu. Voskoboynik, I.S. Nosulenko, G.G. Berest, T. Sergeieva, S.Okovytyy, O.V. Karpenko, B.O. Priymenko, S.I. Kovalenko (2018). Synthesis, tautomerism and antiradical activity of 1-methyl-6-(2-(aryl-(hetaryl-))-2-oxoethyl)pteridine-2,4,7(1H, 3H, 6H)-triones. J. Heterocyclic Chem. 4: 1033-1041; DOI: 10.1002/jhet.3135.
·       Voskoboynik O.Yu., Shishkina S.V., Kovalenko S.I. (2018). [1,2,4]Triazino[2,3-c]quina­zolines 3. Reaction of 3- (2-aminophenyl) -6-R-1,2,4-triazin-5 (2H)-ones with aryliso­(thio)cyanates: structure and anticancer activity of products. Chem. Heterocycl. Compd. 54(7): 717-728. DOI: https://doi.org/10.1007/s10593-018-2338-3.
·       Antypenko L,, Meyer F., Kholodnyak O., Jirásková T., Troianova A., Buhaiova V., Cao Surui, Sadykova Z., Kovalenko S., Garbe L., Steffens K. (2018). Novel acyl thiourea derivatives: synthesis, antifungal activity, gene toxicity, drug-like screening and molecular docking. Archive der Pharmazie, 1–14. https://doi.org/10.1002/ardp.201800275.
·       Yu. V. Martynenko, O. M. Antypenko, О. A. Brazhko, I. B. Labenska, S. I. Kovalenko (2019). Directed search of biologically active compounds among hydrogenated isoindolylalkyl(alkaryl-, aryl-)carboxylic acids with quinazoline fragment that influence on the carbohydrate metabolism: design, synthesis and modification. Acta Chim. Slov. 66: 145-154. DOI: 10.17344/acsi.2018.4731.
·       Yu. Martynenko, O. Antypenko, I. Nosulenko, G. Berest, S. Kovalenko (2019). Directed search of anti-inflammatory agents among (3H-quinazoline-4-ylidene)hydrazides of N-protected amino acids and their heterocyclization products. Anti-Inflammatory & Anti-Allergy Agents in Med. Chem. 19(1):. 60-71. DOI: 10.2174/1871523018666190115092215.
·       L. Logoyda, S. Kovalenko, Ahmed M. Abdel-Medied, I. Zhulkevych, I. Drapak, I. Demchuk, O. Netsyuk(2019).HPLC method development for the analysis of bisoprolol in combined dosage form containing bisoprolol and enalapril and vitro dissolution studied International Journal of Applied Pharmaceutics. (Int J App Pharm). 11(3): 186-194. DOI: http://dx.doi.org/10.22159/ijap.2019v11i3.32391
·           O. Yu. Voskoboynik, O. S. Kolomoets, I. S. Nosulenko, G. G. Berest, Bilyi А.К.,O. V. Karpenko, I. F. Belenichev, S. I. Kovalenko (2019). Synthesis, modification and anticonvulsant activity of 3'-R-spiro[indoline-3,6'-[1,2,4]triazino[2,3-c]quinazolin]-2,2'(7'H)-diones dirivatives. J. Heterocyclic Chem. 56(5): 1605-1612. DOI: 10.1002 / jhet.3541.
·       M.S. Kazunin, A. Yu. Voskoboinik, O. M. Shatalova, L. N. Maloshtan, S. I. Kovalenko (2019). Amides of substituted 3-(pteridin-6-yl)propanoic acids: synthesis, spectral characteristics and cytotoxic activity. Chem. Heterocycl. Compd. 55(4/5): 408–415.
·       Antypenko L., Sadykova Z., Shabelnyk K., Hassan F, Steffens Karl, Kovalenko S., Meyer Vera, Garbe Leif. (2019). Synthesis and mode of action studies of novel {2‐(3‐R‐1H‐1,2,4‐triazol‐5‐yl)phenyl}amines to combat pathogenic fungi. Archive der Pharmazie. e1900092. https://doi.org/10.1002/ardp.201900092.
·       Drapak, B. Zimenkovsky, L. Perekhoda, S. Kovalenko, L. Logoyda (2019). LC-MS/MS method development and validation for the determination of cardiazol in human plasma. International Journal of Applied Pharmaceutics (Int J App Pharm). 11(4): 380-385. DOI: http://dx.doi.org/10.22159/ijap.2019v11i4.33482.
·       Drapak, B. Zimenkovsky, L. Perekhoda, S. Kovalenko, L. Logoyda (2019). Development and validation of LC-MS/MS method for estimation of urocarb in human plasma. International Journal of Applied Pharmaceutics (Int J App Pharm). 11(5): 125-130. DOI:  https://doi.org/10.22159/ijap.2019v11i5.33873.
·       M.S. Kazunin, O.Yu. Voskoboynik, I.S. Nosulenko, G.G. Berest, S.V. Kholodnyak, B.O. Pryymenko, S.I. Kovalenko(2019).Synthesis, antiradical and antimicrobial activity of new pteridine-2,4,7-trione derivatives. J. Heterocyclic Chem. 1-13. DOI: 10.1002/jhet.3774.
·       V. Stavytskyi, O. Voskoboinik, O. Antypenko, N. Krasovska, K. Shabelnyk, I. Konovalova, S. Shishkyna, S. Kholodniak, S. Kovalenko. (2020). Tandem heterocyclization of 2-(azolyl-(azinyl-))anilines as an efficient method for preparation of substituted pyrrolo[1,2-a]azolo-(azino-)[c]quinazolines. J. Heterocyclic Chem. 57(3): 1249-1260. https://doi.org/10.1002/jhet.3862.
·       V. Stavytskyi, О. Voskoboinik, М. Kazunin, I. Nosulenko, S. Shishkina, S. Kovalenko (2020). Substituted pyrrolo[1,2-a][1,2,4]triazolo-([1,2,4]triazino-)[c]quinazoline-4a(5a)-propanoic acids: synthesis, spectral characteristics and anti-inflammatory activity. Voprosy khimii i khimicheskoi tekhnologii. 1: 61-70. DOI: 10.32434/0321-4095-2020-128-1-61-70. (Ukraine).
·       Logoyda L., Kovalenkо S., Gaafar M., Abdel-Megied A. M., Elbarbry F. A. (2020).A validated LC-MS/MS method for the quantification of amlodipine, bisoprolol, enalapril and enalaprilat-Application to pharmacokinetic study in healthy volunteers. Microchemical Journal, 155, 104700. doi:10.1016/j.microc.2020.104700.
·       M. S. Kazunin, O. Yu. Voskoboynik, S. V. Shishkina, O. M. Antypenko, S. I. Kovalenko. (2020). A Simple and Convenient Method for the Synthesis of 1-Methyl-7-arylfuro[3,2-g]­pteridine-2,4(1H,3H)-diones and Their Substituted Derivatives. Acta Chim. Slov. 67: 586–593.. DOI: 10.17344/acsi.2019.5601.
·       O.Yu.Voskoboinik, V.V. Stavytskyi, O.M. Antypenko, M.S. Kazunin, D.V. Kravtsov, S.V. Shishkina S.I. Kovalenko. (2020). Synthesis and structure of pyrido[1,2-a]quinazoline condensed derivatives. Synthetic Communications. 50(13), 2043–2051. https://doi.org/10.1080/00397911.2020.1762223.
·       O.V. Kholodniak, M.S. Kazunin, F. Meyer, S. I. Kovalenko, K. G. Steffens. (2020). Novel N-cycloalkylcarbonyl-N¢-aryl-thioureas: Synthesis, Design, Antifungal Activity and Gene Toxicity. Chemistry and Biodiversity, 17, е2000212. DOI: 10.1002/cbdv.202000212.
·       V. Stavytskyi, O. Antypenko, I. Nosylenko, G. Berest, O. Voskoboinik, S. Kovalenko (2020).Substituted 3-R-2,8-Dioxo-7,8-dihydro-2H-pyrrolo[1,2-a][1,2,4]triazino[2,3-c]quinazoline-5a(6H)carboxylic Acids and Their Salts – a Promising Class of Anti-inflammatory Agents. Anti-Inflammatory & Anti-Allergy Agents in Med. Chem. DOI: 10.2174/1871523019666200505073232
·       Martynenko Yu. V., Berest G. G., Bukhtiayrova N. V., Belenichev I. F., Voskoboinik O. Yu., Kovalenko S. I. (2020). 2-[(3-Aminoalkyl-(alkaryl-,aryl-))-1H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity. Turk. J. Chem, doi:10.3906/kim-2002-24.
 
LANGUAGES
Ukrainian, Russian,– native; fluent; English – with a dictionary.